| Characteristic | Overall N = 7621 |
Q1 N = 1911 |
Q2 N = 1911 |
Q3 N = 1891 |
Q4 N = 1911 |
p-value2 |
|---|---|---|---|---|---|---|
| Age | 71 (62, 79) | 77 (67, 84) | 74 (65, 80) | 70 (63, 76) | 64 (55, 73) | <0.001 |
| Female sex | 279 (37%) | 85 (45%) | 89 (47%) | 58 (31%) | 47 (25%) | <0.001 |
| Smoking | 0.6 | |||||
| never | 269 (36%) | 57 (31%) | 75 (40%) | 69 (38%) | 68 (36%) | |
| current | 211 (28%) | 56 (31%) | 45 (24%) | 53 (29%) | 57 (30%) | |
| prior | 262 (35%) | 70 (38%) | 66 (35%) | 62 (34%) | 64 (34%) | |
| Hypertension | 418 (55%) | 123 (65%) | 114 (60%) | 96 (51%) | 85 (45%) | <0.001 |
| Diabetes | 85 (11%) | 27 (14%) | 27 (14%) | 19 (10%) | 12 (6.3%) | 0.040 |
| Previous ischemic event | 97 (13%) | 30 (16%) | 24 (13%) | 27 (14%) | 16 (8.4%) | 0.14 |
| SVD score | <0.001 | |||||
| 0 | 310 (41%) | 49 (26%) | 72 (38%) | 81 (43%) | 108 (57%) | |
| 1 | 195 (26%) | 47 (25%) | 53 (28%) | 42 (22%) | 53 (28%) | |
| 2 | 148 (19%) | 54 (28%) | 42 (22%) | 37 (20%) | 15 (7.9%) | |
| 3 | 73 (9.6%) | 30 (16%) | 14 (7.3%) | 19 (10%) | 10 (5.2%) | |
| 4 | 36 (4.7%) | 11 (5.8%) | 10 (5.2%) | 10 (5.3%) | 5 (2.6%) | |
| Admission NIHSS | 4.0 (2.0, 7.0) | 5.0 (2.0, 9.0) | 3.0 (2.0, 8.0) | 4.0 (2.0, 8.0) | 3.0 (2.0, 5.0) | <0.001 |
| 1 Median (Q1, Q3); n (%) | ||||||
| 2 Kruskal-Wallis rank sum test; Pearson’s Chi-squared test | ||||||
SVD burden and PA
Pooled TALOS and RESIST data
Andreas Gammelgaard Damsbo
2025-01-13
Intro
Small vessel disease (SVD) is a major contributor to stroke and cognitive decline.
Hypertension, diabetes, and smoking are well-established contributors to SVD burden, the role of physical activity (PA) is still debated.
We aimed to investigate the association of SVD burden, PA and classical risk factors in acute ischemic stroke (AIS) patients.
Pooled data from TALOS and RESIST trials
SVD scoring scale
| Feature | Score |
|---|---|
| Cerebral microbleed | 1 |
| Lacune | 1 |
| Beginning WMH confluence (Fazeka) | 1 |
| Moderate-severe atrophy (GCA) | 1 |
Features 1/2
Features 2/2
Baseline table
SVD distribution
[[1]]
Analyses
Ordinal logistic regression
| Characteristic |
Univariable
|
Multivariable
|
|||
|---|---|---|---|---|---|
| N | OR1 | 95% CI1 | OR1 | 95% CI1 | |
| Age | 762 | 1.09 | 1.08, 1.11 | 1.08 | 1.07, 1.10 |
| Female sex | 762 | 1.19 | 0.91, 1.55 | 0.89 | 0.66, 1.20 |
| Smoking | 742 | ||||
| never | — | — | — | — | |
| current | 1.01 | 0.73, 1.41 | 1.57 | 1.09, 2.28 | |
| prior | 1.69 | 1.24, 2.32 | 1.33 | 0.96, 1.86 | |
| Hypertension | 761 | 2.89 | 2.21, 3.79 | 1.79 | 1.33, 2.40 |
| Diabetes | 761 | 1.50 | 1.00, 2.23 | 1.35 | 0.88, 2.08 |
| Previous ischemic event | 758 | 2.57 | 1.73, 3.81 | 2.08 | 1.38, 3.14 |
| Pre-stroke PA quartile | 762 | ||||
| Q4 | — | — | — | — | |
| Q3 | 2.04 | 1.39, 3.00 | 1.53 | 1.01, 2.32 | |
| Q2 | 2.21 | 1.52, 3.23 | 1.18 | 0.78, 1.79 | |
| Q1 | 3.92 | 2.69, 5.73 | 1.78 | 1.16, 2.73 | |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||||
Adding interaction terms
| No adjustment | No adjustment | PA adjustment | PA adjustment | PA interaction | PA interaction | |
| Characteristic | OR | 95% CI | OR | 95% CI | OR | 95% CI |
| Smoking | ||||||
| - never | — | — | — | — | — | — |
| - current | 1.63 | 1.14, 2.34 | 1.55 | 1.08, 2.23 | 1.28 | 0.62, 2.69 |
| - prior | 1.44 | 1.04, 2.00 | 1.41 | 1.02, 1.97 | 1.76 | 0.86, 3.64 |
| Hypertension | 1.91 | 1.43, 2.54 | 1.88 | 1.41, 2.50 | 2.12 | 1.18, 3.83 |
| Diabetes | 1.46 | 0.96, 2.22 | 1.40 | 0.92, 2.13 | 1.81 | 0.56, 5.38 |
| Previous ischemic event | 2.28 | 1.52, 3.41 | 2.21 | 1.48, 3.31 | 1.47 | 0.56, 3.73 |